Invitrogen™ MMS19 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596306

Catalog No. PIPA596306

Description

Immunogen sequence: FAGLLNKHPA GQQLDEFLQL AVDKVEAGLG SGPCRSQAFT LLLWVTKALV LRYHPLSSCL TARLMGLLSD PELGPAAADG FSLLMSDCTD VLTRAGHAEV RIMFRQRFFT DNVPALVQGF HAAPQDVKPN YLKGLSHVLN RLPKPVLLPE LPTLLSLLLE ALSCPDCVVQ LSTLSCLQPL LLEAPQVMSL HVDTLVTKFL NLSSSPSMAV RIAALQCMHA LTRLPTPVLL PYKPQVIRAL AKPLDDKKRL VRKEAVSARG EWFLLGSPGS; Positive Samples: Mouse thymus; Cellular Location: Cytoplasm, Nucleus, cytoskeleton, spindle.

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Specifications

• Antigen: MMS19
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MMS19
• Gene Alias: 2410001K24Rik; 2610042O15Rik; AI316855; C79368; C86341; hMMS19; homolog of yeast MMS19; incisor protein; MET18; MET18 homolog; Mms19; MMS19 (MET18 S. cerevisiae); MMS19 cytosolic iron-sulfur assembly component; MMS19 homolog, cytosolic iron-sulfur assembly component; MMS19 nucleotide excision repair homolog; MMS19 nucleotide excision repair homolog (S. cerevisiae); MMS19 nucleotide excision repair protein homolog; MMS19 nucleotide excision repair-like; Mms19l; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 72199
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.03 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9D071
• Gene Symbols: MMS19
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 761-1030 of human MMS19 (NP_0717574).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG