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MMS19 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 160151AP

Catalog No. 50-173-0644


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Description

Description

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
Specifications

Specifications

MMS19
0.17 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q96T76, Q9D071
hMMS19, MET18, MET18 homolog, MMS19, MMS19 like protein, MMS19L
Rabbit
IgG
150 μL
-20°C
Primary
171124, 64210, 72199
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
MMS19
Liquid
Mms19
MMS19 Fusion Protein Ag8792
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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