MMS19 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 160151AP
DescriptionKey component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|hMMS19, MET18, MET18 homolog, MMS19, MMS19 like protein, MMS19L|
|171124, 64210, 72199|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|MMS19 Fusion Protein Ag8792|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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