Invitrogen™ MOB1B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144144

Catalog No. FEPA5144144

Description

MOB1B Polyclonal Antibody for ICC/IF, IHC (P), IP, ELISA

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Specifications

• Antigen: MOB1B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MOB1B
• Gene Alias: MOB4A; MOBKL1A
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 92597
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry
• Concentration: 3 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
• Gene Accession No.: Q7L9L4
• Gene Symbols: MOB1B
• Immunogen: Recombinant Human MOB kinase activator 1B protein (2-216AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG