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MORF4 Mouse anti-Human, Clone: OTI5A8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526444

Catalog No. PIMA526444


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Description

Description

Cellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines with each other have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype. Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that might allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.
Specifications

Specifications

MORF4
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Liquid
MORF4
Human recombit protein fragment corresponding to amino acids 1-255 of MORF4 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI5A8
Unconjugated
MORF4
CSR, CSRB, SEN, SEN1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10934
Documents
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