MORF4 Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI5F2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526430
DescriptionCellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines with each other have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype. Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that might allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Human recombit protein fragment corresponding to amino acids 1-255 of MORF4 produced in E.coli|
|Canine, Human, Mouse, Non-human primate, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|CSR, CSRB, SEN, SEN1|
|-20° C, Avoid Freeze/Thaw Cycles|
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