Mouse anti-Aminopeptidase N/CD13, Clone: APN/514, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2446820.02MG
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), ImmunofluorescenceAminopeptidase N/CD13 Monoclonal antibody specifically detects Aminopeptidase N/CD13 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, Immunofluorescence.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|Recombinant human CD13 protein|
|Angiogenesis, Cellular Markers, Hematopoietic Stem Cell Markers, Immunology, Mesenchymal Stem Cell Markers, Stem Cell Markers|
|Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence|
|Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 1 - 2 ug/ml|
|alanyl (membrane) aminopeptidase, Alanyl aminopeptidase, Aminopeptidase M, aminopeptidase N, AP-M, AP-N, CD13 antigen, CD13APN, EC 3.4.11, EC 18.104.22.168, gp150, LAP1, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, P150, PEPNhAPN|
|Protein A or G purified|
|Store at 4C.|
|This MAb recognizes an extracellular epitope of an integral membrane glycoprotein of 150kDa, identified as CD13. This antigen is present on most cells of myeloid origin including granulocytes, monocytes, mast cells, and GM-progenitor cells. It is also expressed by the majority of AML, CML in myeloid blast crisis, and in a smaller fraction of lymphoid leukemias. It is absent from normal lymphocytes, platelets and erythrocytes. CD13 is also present on fibroblasts; endothelial cells, epithelial cells from renal proximal tubules and intestinal brush border, bone marrow stromal cells, osteoclasts, and cells lining bile duct canaliculi. CD13 is identical to aminopeptidase N (APN), a prominent membrane-bound metalloprotease present on the surface of intestinal brush border and renal tubules. CD13 plays a role in metabolism of biologically active peptides, in phagocytosis, and in bactericidal/tumoricidal activities. It also serves as a receptor for human coronaviruses (HCV). The lineage-restricted pattern of expression of CD13 within the hemopoietic compartment suggests that it may be important in myeloid cell differentiation.|
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