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Mouse anti-beta 2-Microglobulin, Clone: B2M/961, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2444710.02MG

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Catalog No. NBP24447100


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Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

beta 2-Microglobulin Monoclonal antibody specifically detects beta 2-Microglobulin in Human, Primate samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, Immunofluorescence.
Specifications

Specifications

beta 2-Microglobulin
B2M/961
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Purified
B2M
Full length recombinant human B2M protein
12 kDa
0.02 mg
Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology
Primary
567
Human, Primate
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
0.2mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
P61769
beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin
Mouse
IgG2b Kappa
Protein A or G purified
RUO
Store at 4C.
Monoclonal
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
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