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Mouse anti-beta 2-Microglobulin, Clone: B2M/961, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2444710.2MG

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Catalog No. NBP24447102

This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.



Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence



beta 2-Microglobulin
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Full length recombinant human B2M protein
12 kDa
0.2 mg
Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology
Human, Primate
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin
IgG2b Kappa
Protein A or G purified
Store at 4C.
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
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