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Mouse anti-beta 2-Microglobulin, Clone: C21.48A1, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2444700.1MG

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Catalog No. NBP24447001


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Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

beta 2-Microglobulin Monoclonal antibody specifically detects beta 2-Microglobulin in Human, Primate samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.
Specifications

Specifications

beta 2-Microglobulin
C21.48A1
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin
Mouse
IgG2b Kappa
Protein A or G purified
RUO
Store at 4C.
Monoclonal
The antibody recognizes the hidden determinant of beta-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain. beta-2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
Flow Cytometry, SDS-Page, Immunofluorescence
0.2 mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Purified
B2M
Soluble beta 2 microglobulin
12 kDa
0.1 mg
Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology
Primary
567
Human, Primate
Documents
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