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Mouse anti-Blood Group Lewis b, Clone: SPM194, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2445970.02MG

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Catalog No. NBP24459700


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Description

Description

Ensure accurate, reproducible results in Immunohistochemistry (Paraffin), Immunofluorescence

Fucosyltransferase 3/FUT3 Monoclonal antibody specifically detects Fucosyltransferase 3/FUT3 in Human, Guinea Pig samples. It is validated for Immunohistochemistry-Paraffin, Immunofluorescence.
Specifications

Specifications

Blood Group Lewis b
SPM194
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Purified
FUT3
Mucin isolated from a human ovarian cyst fluid
45 kDa
0.02 mg
Store at 4C.
Monoclonal
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
Immunohistochemistry (Paraffin), Immunofluorescence
0.2mg/mL
Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
P21217
alpha-(1,3/1,4)-fucosyltransferase, Blood group Lewis alpha-4-fucosyltransferase, CD174, EC 2.4.1, EC 2.4.1.65, FT3B, Fucosyltransferase 3, fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group), Fucosyltransferase III, FucT-III, galactoside 3(4)-L-fucosyltransferase, LEfucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood groupincluded), Les, Lewis FT, MGC131739
Mouse
IgG1 Kappa
Protein A or G purified
RUO
Primary
2525
Human, Guinea Pig
Documents
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