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MilliporeSigma™ Mouse anti-Bmi-1, Clone: F6, Alexa Fluor 647,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ 05637AF647

Catalog No. 05-637-AF647


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Description

Description

Specifically detects Bmi-1 clone: F6 in Human, Monkey samples, and it is validated for Immunocytochemistry

Polycomb complex protein BMI-1 (UniProt P25916; also known as B lymphoma Mo-MLV insertion region 1, Polycomb group RING finger protein 4) is encoded by the Bmi1 (also known as AW546694, Bmi-1, Pcgf4) gene (Gene ID 12151) in murine species. Bmi1 is a member of the polycomb group (PcG) family of evolutionarily conserved gene silencers involved in cell fate decisions and body pattern during development. Bmi1 is an important regulator of self-renewal of hematopoietic and neural stem cells, as well as cancer stem cells (CSCs). Bmi1 is a main constituent of the polycomb repressive complex 1 (PRC1) and pariticipates in PRC-mediated gene silencing by promoting monoubiquitination of H2A. Bmi1 overexpression is reported in many different human cancers and high level of Bmi1 is considered as a poor prognostic marker. Bmi1 targets genes involved in transforming growth factor-β/bone morphogenetic protein (TGF-beta/BMP), endoplasmic reticulum (ER) stress, and WNT pathways. Bmi itself is transcriptionally regulated by c-Myc and E2F1 transcription factors.
Specifications

Specifications

Bmi-1
F6
Purified mouse conjugate antibody in PBS with 15mg/mL BSA and 0.1% sodium azide.
Purified
Murine
IgG1
100μL
Epigenetics and Nuclear Function
Primary
NP_031578.2
Immunocytochemistry
Alexa Fluor 647
P25916
Bmi1; Bmi-1; Pcgf4
Recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1.
Protein G Purified
RUO
Stable for one year at 2°C to 8°C from date of receipt.
Monoclonal
Human, Monkey
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