Mouse anti-CCR5, Clone: 12D1, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2444830.1MG
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Frozen), ImmunofluorescenceCCR5 Monoclonal antibody specifically detects CCR5 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Frozen, Immunofluorescence.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|Human native CCR5 protein|
|Alzheimers Research, Cancer, Chemokine Research, Chemokines and Cytokines, Cytokine Research, GPCR, Immunology, Innate Immunity, Neurodegeneration, Neuroscience, Signal Transduction|
|Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence|
|Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml|
|C-C CKR-5, C-C motif chemokine receptor 5 A159A, CCCKR5, CC-CKR-5FLJ78003, CCR-5, CD195, CD195 antigen, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemr13, CKR5, CKR-5, HIV-1 fusion coreceptor, IDDM22CMKBR5C-C chemokine receptor type 5|
|Protein A or G purified|
|Store at 4C.|
|Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.|
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