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Mouse anti-CD37, Clone: IPO-24, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2447500.02MG

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Catalog No. NBP24475000


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Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

CD37 Monoclonal antibody specifically detects CD37 in Human samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.
Specifications

Specifications

CD37
IPO-24
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
CD37 antigentetraspanin-26, CD37 molecule, cell differentiation antigen 37, GP52-40, leukocyte antigen CD37, MGC120234, Tetraspanin-26, Tspan-26, TSPAN26leukocyte surface antigen CD37
Mouse
IgG2b Kappa
0.02 mg
Cellular Markers, Immunology
Primary
951
Human
Flow Cytometry, SDS-Page, Immunofluorescence
0.2 mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Purified
CD37
Spleen cells of a patient with hairy cell leukemia
Protein A or G purified
RUO
Store at 4C.
Monoclonal
Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V; Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin's lymphoma (B-NHL).
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