Mouse anti-CD46, Clone: 122.2, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2252220.02MG
DescriptionCD46 Monoclonal antibody specifically detects CD46 in Human samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.
|PBS with 0.05% BSA. with 0.05% Sodium Azide|
|A recombinant protein fragment specific for human CD46 was used as the immunogen.|
|Protein G purified|
|Store at 4C.|
|CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.|
|Flow Cytometry, SDS-Page, Immunofluorescence|
|Flow Cytometry 0.5-1ug/million cells in 0.1ml, SDS-Page, Immunofluorescence 0.5-1ug/ml|
|AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen|
|Cancer, Cell Biology, Cellular Markers, Immunology|
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