CD46 Antibody (122.2), Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2252220.02MG

Catalog No. NBP22522202

Description

CD46 Monoclonal specifically detects CD46 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Functional, Immunofluorescence.

Specifications

• Antigen: CD46
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Dilution: Flow Cytometry 0.5-1ug/million cells in 0.1ml, SDS-Page, Immunofluorescence 0.5-1ug/ml
• Gene Accession No.: NP_002380
• Gene Symbols: CD46
• Immunogen: A recombinant protein fragment specific for human CD46 was used as the immunogen.
• Quantity: 0.02 mg
• Research Discipline: Cancer, Cell Biology, Cellular Markers, Immunology
• Gene ID (Entrez): 4179
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, SDS-Page, Immunofluorescence
• Clone: 122.2
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ

For Research Use Only