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Mouse anti-CD46, Clone: 169-1-E4.3, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2446710.02MG

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Catalog No. NBP24467100


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Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

CD46 Monoclonal antibody specifically detects CD46 in Human, Baboon, Equine (Negative) samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.
Specifications

Specifications

CD46
169-1-E4.3
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Mouse
IgG2a Kappa
0.02 mg
Cancer, Cell Biology, Cellular Markers, Immunology
Primary
4179
Human, Baboon, Equine (Negative)
Flow Cytometry, SDS-Page, Immunofluorescence
0.2 mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Purified
CD46
Stimulated human leukocytes
Protein A or G purified
RUO
Store at 4C.
Monoclonal
Recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.
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