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CD70 Mouse anti-Human, Brilliant Violet 786, Clone: Ki-24, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 565338
Description
The Ki-24 monoclonal antibody specifically binds to human CD70. CD70 is a type II transmembrane glycoprotein and member of the TNF Superfamily. CD70 is also known as Tumor necrosis factor ligand superfamily member 7 (TNFSF7), CD27 ligand (CD27-L, CD27L, CD27LG), and KI-24 antigen. The CD70 antigen immunoprecipitates as five bands (50, 70, 90, 100 and 160 kDa) under non-reducing conditions. CD70 is strongly expressed on Reed-Sternberg cells, some activated T or B cells and Epstein Barr Virus (EBV)-positive lymphoblastoid cell lines. CD70 plays roles in the activation, proliferation and differentiation of B cells and T cells including the enhanced production of cytotoxic T cells.
The antibody was conjugated to BD Horizon BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 786-nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60-nm filter).
Specifications
CD70 | |
Monoclonal | |
Brilliant Violet 786 | |
Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
Affinity Purified | |
RUO | |
Human | |
IgG3 κ |
Flow Cytometry | |
Ki-24 | |
CDw70; CD27 ligand; CD27-L; CD27L; CD27LG; Ki-24 antigen; TNFSF7 | |
Mouse | |
50 Tests | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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