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DOG1/TMEM16A Antibody (DG1/447), Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP2443780.1MG
Description
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
DOG1/TMEM16A Monoclonal specifically detects DOG1/TMEM16A in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.Specifications
DOG1/TMEM16A | |
Monoclonal | |
0.2mg/mL | |
Flow Cytometry 5 - 10 ul/million cells in 0.1ml, Immunohistochemistry-Paraffin 1:100-1:200, Immunofluorescence 1:50 - 1:100 | |
ANO1, anoctamin 1, DOG1, ORAOV2, TAOS2, TMEM16A | |
Mouse | |
Protein A or G purified | |
RUO | |
55107 | |
Human | |
Purified |
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence | |
DG1/447 | |
Unconjugated | |
10mM PBS and 0.05% BSA with 0.05% Sodium Azide | |
TMEM16A | |
Recombinant human DOG-1 protein | |
0.1 mg | |
Primary | |
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%. | |
Store at 4C. | |
IgG1 κ |
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