Mouse anti-Elastase, Clone: CELA3B/1218, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2448120.02MG
Ensure accurate, reproducible results in ELISA, Flow Cytometry, ImmunofluorescenceElastase Monoclonal antibody specifically detects Elastase in Human samples. It is validated for Western Blot, Flow Cytometry, SDS-Page, Immunofluorescence.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|Recombinant human CELA3B protein|
|Protein A or G purified|
|Store at 4C.|
|This MAb recognizes a protein of ~17kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.|
|Western Blot, Flow Cytometry, SDS-Page, Immunofluorescence|
|Western Blot, Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml|
|CBPP, cholesterol-binding pancreatic protease, chymotrypsin-like elastase family member 3B, chymotrypsin-like elastase family, member 3B, E1, EC 3.4.21, EC 18.104.22.168, EL-1, ELA3B, elastase 1, elastase 3B, pancreatic, Elastase IIIB, elastase-3B, fecal elastase 1, pancreatic elastase 1, pancreatic endopeptidase E, Protease E, proteinase E|
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