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Mouse anti-EMI1, Clone: EMI1/1176, Novus Biologicals™

Mouse Monoclonal Antibody

$129.00 - $299.00

Specifications

Antigen EMI1
Clone EMI1/1176
Concentration 0.2mg/mL
Immunogen Recombinant fragment (203 amino acid residues between aa 1-250) of human EMI1 protein
Gene ID (Entrez) 26271
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
NBP24434400 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2443440.02MG
0.02 mg Each for $129.00
Add to cart
 
NBP24434401 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2443440.1MG
0.1 mg Each for $299.00
Add to cart
 
NBP24434402 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2443440.2MG
0.2 mg This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Ensure accurate, reproducible results in Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

EMI1 Monoclonal antibody specifically detects EMI1 in Human samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry-Paraffin, Immunofluorescence.
Specifications

Specifications

EMI1
0.2mg/mL
26271
Monoclonal
Mouse
IgG2a Kappa
Purified
RUO
Protein A or G purified
EMI1/1176
Recombinant fragment (203 amino acid residues between aa 1-250) of human EMI1 protein
1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Primary
It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Unconjugated
Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Store at 4C.

For Research Use Only

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