HLA-ABC Mouse anti-Human, PE, Clone: EMR8-5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 565291
The EMR8-5 monoclonal antibody recognizes a conserved epitope expressed on denatured human Major Histocompatibility Complex (MHC) Class I antigen heavy chain proteins, also known as, HLA (Human Leucocyte Antigens): HLA-A, HLA-B, and HLA-C (HLA-ABC). MHC Class I molecules are heterodimers that consist of a ∽40-45 kDa transmembrane alpha chain subunit that is highly polymorphic and noncovalently associated with invariant β 2-microglobulin. MHC Class I antigens are normally expressed on most all nucleated cells. They can be highly expressed on certain activated cells or cells treated with a variety of agents including cytokines or inflammatory mediators. In contrast, they may be very lowly expressed on certain virus-infected or tumor cells. HLA class I antigens expressed by thymic epithelial cells are involved in the positive and negative selection of CD8+ T cells and their TCR repertoire during T cell maturation within the thymus. In the periphery, these HLA antigens serve to present antigens for the generation of effector and memory CD8+ T cell responses. MHC Class I recognition by certain NK receptors can protect target cells from NK cell-mediated lysis. The EMR8-5 antibody is useful for staining HLA Class I molecules found in formalin-fixed cells or paraffin-embedded tissue sections.
|HLA-A, HLA-B, HLA-C; HLAA, HLAB, HLAC; HLA-A,B,C|
|Human HLA-A Recombinant Protein|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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