CD41a Mouse anti-Human, Brilliant Violet 711, Clone: HIP8, BD Optibuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 740778

Catalog No. BDB740778

Description

The HIP8 monoclonal antibody specifically binds to the α -chain of CD41. CD41 is also known as Integrin α IIb or Platelet GPIIb. The calcium-dependent complex of CD41 and CD61 ( β 3 integrin or GPIIIa) is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex is the receptor for fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation. CD41 (clone HIP8) completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes.

Specifications

• Antigen: CD41a
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: ITGA2B; Integrin alpha-2b (αIIb); Platelet glycoprotein IIb (GPIIb)
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: HIP8
• Conjugate: Brilliant Violet 711
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Purified platelet membrane glycoproteins
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only