CD44 Mouse anti-Human, Brilliant Violet 650, Clone: G44-26 (also known as C26), BD Optibuild™
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 740577
The G44-26 monoclonal antibody specifically binds to the 80-95 kDa, glycosylated type I transmembrane protein, also known as phagocytic glycoprotein-1 (Pgp-1). CD44 is the receptor for hyaluronic acid. CD44 is expressed on leucocytes, erythrocytes, epithelial cells and weakly on platelets. CD44 is also called extracellular matrix receptor type III and has functional roles in cell migration, lymphocyte homing and adhesion during hematopoiesis and lymphocyte activation. This antibody is suitable for staining formalin-fixed, paraffin-embedded tissue sections using citrate buffer pretreatment. This antibody recognizes the epitope 1 of CD44 antigen according to the HLDA workshop studies.
The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 650-nm. BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination.
|G44-26 (also known as C26)|
|Brilliant Violet 650|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Phagocytic glycoprotein 1; Pgp-1; H-CAM; Hermes; ECMR III; HUTCH-1|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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