CD64 Mouse anti-Human, Brilliant Violet 650, Clone: 10.1, BD Optibuild™
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 740580
The 10.1 monoclonal antibody specifically binds to CD64, a 72 kDa type I transmembrane glycoprotein that is a high affinity receptor for human IgG (FcγRI), especially the IgG1 and IgG3 subclasses. CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. CD64 associates with a signaling FcRγhomodimer to form the functional high affinity FcγRI complex. CD64 functions in both innate and adaptive immune responses and mediates endocytosis, phagocytosis, antigen presentation, antibody-dependent cellular toxicity, cytokine release and superoxide generation.
|Brilliant Violet 650|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|FCGR1; FcRI; Fc-gamma RI; IgG Fc Receptor I; High affinity IgG FcR1|
|Human Rheumatoid synovial fluid cells and fibronectin-purified monocytes|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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