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Mouse anti-Involucrin, Clone: SPM259, Azide Free, Novus Biologicals™

Mouse Monoclonal Antibody

Specifications

Antigen Involucrin
Clone SPM259
Concentration 1.0 mg/mL
Immunogen Purified involucrin from human keratinocytes
Gene Accession No. P07476
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
NBP23440201
View Documents
Novus Biologicals
NBP2344020.1 MG
0.1 mg N/A
NBP23440202
View Documents
Novus Biologicals
NBP2344020.2 MG
0.2 mg N/A N/A N/A
Description

Description

Involucrin Monoclonal antibody specifically detects Involucrin in Human, Porcine, Canine, Primate, Mouse (Negative) samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, CyTOF-ready.
Specifications

Specifications

Involucrin
1.0 mg/mL
P07476
10mM PBS - BSA free with No Preservative
It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ∼115kDa and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
Primary
Mouse
Unconjugated
Protein A purified
Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
SPM259
Purified involucrin from human keratinocytes
3713
Protein A purified
Monoclonal
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
IgG1 Kappa
Purified
RUO
SDS
Product Certifications

For Research Use Only

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