Mouse anti-LAIR1, Clone: 9.1C3, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2443770.1MG
Ensure accurate, reproducible results in Flow Cytometry, ImmunofluorescenceLAIR1 Monoclonal antibody specifically detects LAIR1 in Human samples. It is validated for Flow Cytometry, Immunofluorescence.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|Human Lymphocytes and Large Granular Lymphocytes (LGL)|
|Store at 4C.|
|Recognizes a single protein of 40kDa, identified as the CD305 (LAIR1). It is an inhibitory receptor, expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. This MAb is expressed on CD34 positive hematopoietic progenitors. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. This MAb is identical to LAIR-1, based on the fact that it not only precipitated a protein of 40kDa but it also binds specifically to LAIR-1 cDNA transfected COS7 cells as well as recognizes LAIR-1 fusion protein in ELISA. LAIR-1 expresses on hematopoietic progenitor, implicating its role in the regulation of hematopoiesis at early stage.|
|Flow Cytometry, Immunofluorescence|
|Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunofluorescence 0.5 - 1.0 ug/ml|
|CD305 antigen, CD305leukocyte-associated Ig-like receptor 1, hLAIR1, LAIR-1, leukocyte-associated immunoglobulin-like receptor 1|
|Protein A or G purified|
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