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Mouse anti-LAIR1, Clone: 9.1C3, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2443770.1MG

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Catalog No. NBP24437701

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Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

LAIR1 Monoclonal antibody specifically detects LAIR1 in Human samples. It is validated for Flow Cytometry, Immunofluorescence.


10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Human Lymphocytes and Large Granular Lymphocytes (LGL)
40 kDa
0.1 mg
Store at 4C.
Recognizes a single protein of 40kDa, identified as the CD305 (LAIR1). It is an inhibitory receptor, expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. This MAb is expressed on CD34 positive hematopoietic progenitors. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. This MAb is identical to LAIR-1, based on the fact that it not only precipitated a protein of 40kDa but it also binds specifically to LAIR-1 cDNA transfected COS7 cells as well as recognizes LAIR-1 fusion protein in ELISA. LAIR-1 expresses on hematopoietic progenitor, implicating its role in the regulation of hematopoiesis at early stage.
Flow Cytometry, Immunofluorescence
0.2 mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunofluorescence 0.5 - 1.0 ug/ml
CD305 antigen, CD305leukocyte-associated Ig-like receptor 1, hLAIR1, LAIR-1, leukocyte-associated immunoglobulin-like receptor 1
IgG2 Kappa
Protein A or G purified
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