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Mouse anti-LAIR1, Clone: 9.1C3, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2443770.1MG

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Catalog No. NBP24437701


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Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

LAIR1 Monoclonal antibody specifically detects LAIR1 in Human samples. It is validated for Flow Cytometry, Immunofluorescence.
Specifications

Specifications

LAIR1
9.1C3
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Purified
LAIR1
Human Lymphocytes and Large Granular Lymphocytes (LGL)
40 kDa
0.1 mg
Store at 4C.
Monoclonal
Recognizes a single protein of 40kDa, identified as the CD305 (LAIR1). It is an inhibitory receptor, expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. This MAb is expressed on CD34 positive hematopoietic progenitors. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. This MAb is identical to LAIR-1, based on the fact that it not only precipitated a protein of 40kDa but it also binds specifically to LAIR-1 cDNA transfected COS7 cells as well as recognizes LAIR-1 fusion protein in ELISA. LAIR-1 expresses on hematopoietic progenitor, implicating its role in the regulation of hematopoiesis at early stage.
Flow Cytometry, Immunofluorescence
0.2 mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunofluorescence 0.5 - 1.0 ug/ml
Q6GTX8
CD305 antigen, CD305leukocyte-associated Ig-like receptor 1, hLAIR1, LAIR-1, leukocyte-associated immunoglobulin-like receptor 1
Mouse
IgG2 Kappa
Protein A or G purified
RUO
Primary
3903
Human
Documents
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