Mouse anti-LAIR1, Clone: 9.1C3, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2443770.2MG

Catalog No. NBP24437702

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

LAIR1 Monoclonal antibody specifically detects LAIR1 in Human samples. It is validated for Flow Cytometry, Immunofluorescence.

Specifications

• Antigen: LAIR1
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunofluorescence 0.5 - 1.0 ug/ml
• Gene Accession No.: Q6GTX8
• Gene Symbols: LAIR1
• Immunogen: Human Lymphocytes and Large Granular Lymphocytes (LGL)
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Gene ID (Entrez): 3903
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, Immunofluorescence
• Clone: 9.1C3
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Alias: CD305 antigen, CD305leukocyte-associated Ig-like receptor 1, hLAIR1, LAIR-1, leukocyte-associated immunoglobulin-like receptor 1
• Host Species: Mouse
• Molecular Weight of Antigen: 40 kDa
• Quantity: 0.2 mg
• Primary or Secondary: Primary
• Test Specificity: Recognizes a single protein of 40kDa, identified as the CD305 (LAIR1). It is an inhibitory receptor, expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. This MAb is expressed on CD34 positive hematopoietic progenitors. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. This MAb is identical to LAIR-1, based on the fact that it not only precipitated a protein of 40kDa but it also binds specifically to LAIR-1 cDNA transfected COS7 cells as well as recognizes LAIR-1 fus
• Content And Storage: Store at 4C.
• Isotype: IgG2 κ

For Research Use Only