LAP Mouse anti-Mouse, Alexa Fluor 647, Clone: TW7-16B4, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 565636
The TW7-16B4 monoclonal antibody speci fically binds to Latency-Associated Peptide (LAP), a component of the dimeric Transforming Growth Factor-beta 1 (TGF-β1) propeptide encoded by Tgfb1 . Prior to secretion, the dimeric LAP-TGF-β1 propeptide is cleaved resulting in a biologically inactive form of dimeric TGF-β1 that is noncovalently associated with dimeric LAP (latent TGF-β1). This complex may be expressed on the surface of TGF-β1-producing cells or be further processed by proteolytic removal of LAP to release the biologically active mature form of the soluble TGF-β1 homodimer. Platelets contain TGF-β1 and most nucleated cells, including tumor cells and cells that comprise the innate and adaptive immune system can produce TGF-β1. TGF-β1 is a potent multifunctional cytokine that regulates numerou s processes including development, hematopoiesis, tissue remodeling, wound repair, and immunity as well as cancer and autoimmune diseases.
|Latency-associated peptide; TGFB1; TGFbeta; Transforming growth factor beta|
|Alexa Fluor 647|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Mouse Tgfb1-transduced Cell Line|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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