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Mouse anti-Plasma Cell Marker, Clone: SPM310, Azide Free, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP2344070.1 MG

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Catalog No. NBP23440701


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Description

Description

Plasma Cell Marker Monoclonal antibody specifically detects Plasma Cell Marker in Human, Rat (Negative) samples. It is validated for Immunohistochemistry-Paraffin.
Specifications

Specifications

Plasma Cell Marker
SPM310
Unconjugated
10mM PBS - BSA free with No Preservative
Mouse
IgG2a
0.1 mg
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Monoclonal
Protein A purified
Immunohistochemistry (Paraffin)
1.0 mg/mL
Immunohistochemistry-Paraffin 0.5-1ug/ml
Purified
Pancreatic cancer-related mucin
Protein A purified
RUO
Primary
It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues.
Human, Rat (Negative)
SDS
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Product Certifications
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