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Mouse anti-SOX10, Clone: SOX10/991 + SOX10/1074, Novus Biologicals™

Mouse Monoclonal Antibody

$129.00 - $299.00

Specifications

Antigen SOX10
Clone SOX10/991 + SOX10/1074
Concentration 0.2mg/mL
Immunogen Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag
Gene ID (Entrez) 6663
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
NBP24447600 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2444760.02MG
0.02 mg Each for $129.00
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NBP24447601 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2444760.1MG
0.1 mg Each for $299.00
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NBP24447602 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2444760.2MG
0.2 mg This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Ensure accurate, reproducible results in Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

SOX10 Monoclonal antibody specifically detects SOX10 in Human samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry-Paraffin, Immunofluorescence.
Specifications

Specifications

SOX10
0.2mg/mL
6663
Monoclonal
Mouse
IgG2b Kappa
Purified
RUO
Protein A or G purified
SOX10/991 + SOX10/1074
Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Primary
Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Unconjugated
Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Store at 4C.

For Research Use Only

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