Mouse anti-TOP1MT, Clone: TOP1MT/488, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2443600.02MG
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), ImmunofluorescenceTOP1MT Monoclonal antibody specifically detects TOP1MT in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, SDS-Page, Flow (Intracellular), Immunofluorescence.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|Recombinant full-length human TOP1MT protein|
|Store at 4C.|
|DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.|
|Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence|
|Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml|
|mitochondrial, mitochondrial DNA topoisomerase I, topoisomerase (DNA) I, mitochondrial|
|Protein A or G purified|
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