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Mouse anti-Transgelin/TAGLN/SM22 alpha, Clone: SPM606, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2444360.1MG

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Catalog No. NBP24443601


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Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Transgelin/TAGLN/SM22 alpha Monoclonal antibody specifically detects Transgelin/TAGLN/SM22 alpha in Human, Mouse, Porcine, Primate, Rabbit samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, Immunofluorescence.
Specifications

Specifications

Transgelin/TAGLN/SM22 alpha
SPM606
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Purified
TAGLN
Recombinant full-length human transgelin (TAGLN) protein.
22 kDa
0.1 mg
Store at 4C.
Monoclonal
This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
0.2mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 1 - 2 ug/ml
Q01995
DKFZp686P11128, Protein WS3-10, SM2222 kDa actin-binding protein, SMCCDKFZp686B01212, Smooth muscle protein 22-alpha, TAGLN1, transgelin, transgelin variant 2, WS3-10SM22-alpha
Mouse
IgG1 Kappa
Protein A or G purified
RUO
Primary
6876
Human, Mouse, Porcine, Primate, Rabbit
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