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Invitrogen™ eBioscience™ Mouse IFN-gamma Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of mouse IFN-gamma.

Manufacturer:  Invitrogen™ BMS606FIVE

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Catalog No. 50-112-5452


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse IFN-gamma
Biotin-Conjugate anti-mouse IFN-gamma monoclonal antibody
Streptavidin-HRP
Mouse IFN-gamma Standard lyophilized, 2ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
Specifications

Specifications

P01580
Biotin
15978
Adhesive Plate Covers
5 x 96 tests
5.3 pg/mL
50μL
Mouse
1 hr 20 min
Mouse
Immune interferon, IFG
5%
15.6-1,000 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA Kit
RUO
Serum,Supernatant
Serum,50 μL|Supernatant,50 μL
2-8°C
3 hr 10 min
Ifng
10%
HRP
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