Invitrogen™ Mouse IL-17A Recombinant Protein

E. coli Recombinant Protein

Supplier:  Invitrogen™ RP87884

Catalog No. PIRP87884

Description

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

Specifications

• Accession Number: Q62386
• For Use With (Application): Control, ELISA, Western Blot
• Gene ID (Entrez): 16171
• Name: Mouse IL-17 A (aa 26-158)
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: CTLA8; Ctla-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; Il17a; IL-17 A; ILN; Interleukin; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17 A; interleukin 17 A-like; interleukin-17; Interleukin17A; interleukin-17 A; LOC100339322; R-IL-17-A
• Specific Reactivity: Mouse
• Recombinant: Recombinant
• Purity or Quality Grade: >95%

• Concentration: 200 μg/mL
• Formulation: 10 mM sodium phosphate with 150 mM NaCl and no preservative; pH 7.2
• Molecular Weight (g/mol): 15 kD
• Quantity: 10 μg
• Storage Requirements: -20°C
• Endotoxin Concentration: 0.01 ng/ μg cytokine
• Gene Symbol: IL17A
• Conjugate: Unconjugated
• Form: Liquid