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Invitrogen™ Mouse IL-17A Recombinant Protein
E. coli Recombinant Protein
Supplier: Invitrogen™ RP87886
Description
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).Specifications
Q62386 | |
Control, ELISA, Western Blot | |
16171 | |
Mouse IL-17 A (aa 26-158) | |
E. coli | |
RUO | |
CTLA8; Ctla-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; Il17a; IL-17 A; ILN; Interleukin; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17 A; interleukin 17 A-like; interleukin-17; Interleukin17A; interleukin-17 A; LOC100339322; R-IL-17-A | |
Mouse | |
Recombinant | |
>95% |
200 μg/mL | |
10 mM sodium phosphate with 150 mM NaCl and no preservative; pH 7.2 | |
15 kD | |
100 μg | |
-20°C | |
0.01 ng/ μg cytokine | |
IL17A | |
Unconjugated | |
Liquid |
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