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Mouse IL-17A (aa 26-158), Recombinant Protein, Invitrogen™ Non-distribution product as customer accommodation.

E. coli Recombinant Protein

$160.50 - $1926.00

Specifications

Recombinant Yes
Name Mouse IL-17 A (aa 26-158)
For Use With (Application) Control, ELISA, Western Blot
Concentration 200 µg/mL
Conjugate Unlabeled
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Products 4
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIRP87884 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87884
10 µg
Each for $160.50
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PIRP87885 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87885
25 µg
Each for $289.00
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PIRP87886 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87886
100 µg
Each for $642.00
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PIRP87887 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87887
500 µg
Each for $1,926.00
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Description

Description

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Specifications

Specifications

Yes
Control, ELISA, Western Blot
Unlabeled
10 mM sodium phosphate with 150 mM NaCl and no preservative; pH 7.2
E. coli
-20°C
Q62386
IL17A
>95%
Mouse IL-17 A (aa 26-158)
200 µg/mL
Liquid
CTLA8; Ctla-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; Il17a; IL-17 A; ILN; Interleukin; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17 A; interleukin 17 A-like; interleukin-17; Interleukin17A; interleukin-17 A; LOC100339322; R-IL-17-A
RUO
Mouse
16171
15 kD
SDS
Product Certifications
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