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Invitrogen™ eBioscience™ Mouse IL-17F Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of mouse IL-17F.

Manufacturer:  Invitrogen™ BMS6020

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Catalog No. 50-112-5443


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse IL-17F
Biotin-Conjugate anti-mouse IL-17F polyclonal antibody
Streptavidin-HRP
Mouse IL-17F Standard lyophilized, 4ng/mL upon reconstitution
Sample Diluent
Conjugate Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Calibrator Diluent
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
Specifications

Specifications

Q7TNI7
Biotin
257630
Adhesive Plate Covers
96 tests
10 pg/mL
50μL
Mouse
1 hr 20 min
Mouse
Interleukin 17F, Cytokine ML1
4.2%
62.5-4,000 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA Kit
RUO
Plasma,Serum,Supernatant
Plasma,50 μL|Serum,50 μL|Supernatant,50 μL
2-8°C
4 hr 30 min
Il17f
4.9%
HRP
Documents
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