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Mouse IL-21 (aa 25-146), Recombinant Protein, Invitrogen™ Non-distribution product as customer accommodation.

E. coli Recombinant Protein

$238.00 - $3590.00

Specifications

Recombinant Yes
Name Mouse IL-21 (aa 25-146)
For Use With (Application) Control, ELISA, Western Blot
Concentration 200 µg/mL
Conjugate Unlabeled
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Products 4
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIRP87888 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87888
10 µg
Each for $238.00
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PIRP87889 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87889
25 µg
Each for $449.50
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PIRP87890 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87890
100 µg
Each for $1,130.00
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PIRP87891 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87891
500 µg
Each for $3,590.00
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Description

Description

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
Specifications

Specifications

Yes
Control, ELISA, Western Blot
Unlabeled
PBS with no preservative
E. coli
-20°C
Q9ES17
IL21
>95%
Mouse IL-21 (aa 25-146)
200 µg/mL
Liquid
CVID11; C x 2; il 21; Il21; IL-21; ILN; Interleukin; interleukin 21; interleukin 21-like; Interleukin21; interleukin-21; interleukin-21 isoform; LOC100344172; porcine interleukin-21; Za11
RUO
Mouse
60505
14.2 kD
SDS
Product Certifications
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