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Invitrogen™ eBioscience™ Mouse TGF-beta1 Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of mouse TGF-beta1.

Manufacturer:  Invitrogen™ BMS6084FIVE

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Catalog No. 50-112-5458


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse TGF-beta1
Biotin-Conjugate anti-mouse TGF-beta1 polyclonal antibody
Streptavidin-HRP
Mouse TGF-beta1 Standard lyophilized, 4ng/mL upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
]Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Adhesive Films

Description

Description

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
Specifications

Specifications

P04202
ELISA
Colorimetric Microplate Reader
ELISA Kit
RUO
Plasma,Serum,Supernatant
Plasma,20 μL|Serum,20 μL|Supernatant,20 μL
2-8°C
4 hr
Tgfb1
5.8%
HRP
31.25-2,000 pg/mL
21803
Adhesive Plate Covers
5 x 96 tests
7.8 pg/mL
10 to 40μL (pretreated)
Mouse
1 hr 20 min
Mouse
Camurati-Engelmann disease, DPD1
7.9%
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