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MOV10L1 Rabbit anti-Human, Polyclonal, Invitrogen

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551004

Catalog No. PA551004


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Description

Description

MOV10L1 Polyclonal Antibody detects endogenous levels of MOV10L1 protein.

Isoform 1: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Involved in the primary piRNA metabolic process (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Acts via its ATP-dependent RNA helicase activity: displays 5 ft.-3 ft. RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). {ECO:0000269; PubMed:20534472, ECO:0000269; PubMed:20547853, ECO:0000269; PubMed:23166510, ECO:0000269; PubMed:25762440}.; Isoform 2: May act downstream of MEF2C during heart formation. Acts as a cardiac-specific suppressor of cardiomyocyte hypertrophy and cell cycle progression, suggesting that it may suppress these processes through the regulation of CDKN1A. Such results however require additional evidence. {ECO:0000305; PubMed:11854500}.
Specifications

Specifications

MOV10L1
Polyclonal
Unconjugated
MOV10L1
Liquid
MOV10L1
Synthesized peptide derived from the Internal region of human MOV10L1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ELISA, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q9BXT6
MOV10L1, Putative helicase Mov10l1, Moloney leukemia virus 10-like protein 1, MOV10-like protein 1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
54456
Documents
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