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MPP8 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A303052AT

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Catalog No. 50-156-4138


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

Heterochromatin component that specifically recognizes and binds methylated ′Lys-9′ of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
Specifications

Specifications

MPP8
Polyclonal
TBS with 0.1% BSA and 0.09% sodium azide
Q99549
MPHOSPH8
Between 200 and 250
20 μL
Primary
Human
Antibody
IgG
Western Blot
Unconjugated
MPHOSPH8
HSMPP8, TWA3, mpp8, M-phase phosphoprotein, mpp, M-phase phosphoprotein, mpp8, two hybrid-associated protein 3 with RanBPM
Rabbit
Antigen affinity chromatography
RUO
54737
4° C
Liquid
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