The recommended shelf life for this product is 1 year from date of receipt.Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
|TBS with 0.1% BSA and 0.09% sodium azide|
|HSMPP8, TWA3, mpp8, M-phase phosphoprotein, mpp, M-phase phosphoprotein, mpp8, two hybrid-associated protein 3 with RanBPM|
|Antigen affinity chromatography|
|Between 200 and 250|
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