Invitrogen™ MRC2 Recombinant Rabbit Monoclonal Antibody (5I0I9)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
MA557975	Invitrogen™ MA557975	20 μL
MA557976	Invitrogen™ MA557976	100 μL

Description

Immunogen sequence: DAALPEPNVF LIFSHGLQGC LEAQGGQVRV TPACNTSLPA QRWKWVSRNR LFNLGTMQCL GTGWPGTNTT ASLGMYECDR EALNLRWHCR TLGDQLSLLL GARTSNISKP GTLERGDQTR SGQWRIYGSE EDLCALPYHE VYTIQGNSHG KPCTIPFKYD NQWFHGCTST GREDGHLWCA TTQDYGKDER WGFCPIKSND CETFWDKDQL TDSCYQFNFQ STLSWREAWA SCEQQGADLL SITEIHEQTY INGLLTGYSS TLWIGLNDLD TSGGWQWSDN SPLKYLNWES DQPDNPSEEN CGVIRTESSG GWQNRDCSIA LPYVCKKKPN ATAEPTPPDR WANVKVECEP SWQPFQGHCY RLQAEKRSWQ ESKKACLRGG GDLVSIHSMA ELEFITKQIK QEVEELWIGL NDLKLQMNFE WSDGSLVSFT HWHPFEPNNF RDSLEDCVTI WGPEGRWNDS PCNQSLPSIC KKAGQLSQG.

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

Specifications

• Antigen: MRC2
• Concentration: 1.92 mg/mL
• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q9UBG0
• Gene ID (Entrez): 9902
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 35-513 of human MRC2 (NP_006030.2).
• Product Type: Antibody

• Clone: 5I0I9
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: MRC2
• Gene Alias: CD280; CLEC13E; collagen-binding factor Endo180; C-type lectin domain family 13 member E; C-type mannose receptor 2; Endo180; endocytic receptor (macrophage mannose receptor family); endocytic receptor 180; KIAA0709; Lectin lambda; macrophage mannose receptor 2; mannose receptor C type 2; mannose receptor, C type 2; mKIAA0709; Mrc2; novel lectin; UPARAP; UPAR-associated protein; urokinase-type plasminogen activator receptor-associated protein
• Gene Symbols: MRC2
• Primary or Secondary: Primary
• Purification Method: Protein A