MRE11A Mouse anti-Human, Clone: 12D7, Abnova™
Mouse monoclonal antibody raised against human MRE11A.
Manufacturer: Abnova Corporation MAB12523
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]
|Mouse monoclonal antibody raised against human MRE11A.|
|In PBS, pH 7.4.|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot|
|ELISA Immunofluorescence Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL) Immunoprecipitation Western Blot The optimal working dilution should be determined by the end user.|
|Recombinant protein corresponding to amino acids 182-582 of human MRE11A.|
|Protein G purification|
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