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Caspase-11 Rat anti-Mouse, Unlabeled, Clone: 17D9, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564971

Catalog No. BDB564971

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The 17D9 monoclonal antibody specifically binds to mouse Caspase-11 (CASP-11/Casp11) which is also known as ICH-3. Mouse Caspase-11 is homologous to human Caspase-4 and is encoded by the mouse Casp4 (Caspase 4, apoptosis-related cysteine peptidase) gene. Caspase-11 is a cysteine protease that functions in apoptosis and inflammatory responses. Caspase-11 exists as 38 and 43 kDa pro-caspase forms, and as 30 and 10 kDa active forms. Caspase-11 is an initiator caspase that activates other caspases, including Caspase-1 [ IL-1β -converting enzyme (ICE)], Caspase-3, and Caspase-7, which are involved in executing apoptosis. When Caspase-11 is deficient, cells are unable to process or secrete Interleukin-1 β ( IL-1β ) and demonstrate defective motility in response to certain stimuli. Unlike other caspases that are expressed constitutively, Caspase-11 expression can be upregulated in cells stimulated with certain activators, e.g., macrophages, lymphocytes and hepatocytes stimulated with lipopolysaccharide.



Aqueous buffered solution containing ≤0.09% sodium azide.
IgG2a, κ
Store undiluted at 4°C
Western Blot
CASP-11; Casp11; CASP-4; Casp4; Caspase-4; Caspl; ich-3; Ich3
Affinity Purified
Mouse Caspase-11 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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