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Thermo Scientific™ Lab Vision™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody

Choose one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available.

$163.10 - $655.00

Specifications

Antigen MSH2 (Mismatch Repair Protein 2) Ab-1
Clone 25D12
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Conjugate Unconjugated
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Products 6
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MS1498R7
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Thermo Scientific™
MS1498R7
7mL Each for $459.00
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MS1498RQ
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Thermo Scientific™
MS1498RQ
12mL Each for $477.50
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MS1498S
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Thermo Scientific™
MS1498S
1mL Each for $655.00
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MS1498S0
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Thermo Scientific™
MS1498S0
100μL Each for $163.10
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MS1498S1
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Thermo Scientific™
MS1498S1
500μL Each for $430.50
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MS1498R1
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Thermo Scientific™
MS1498R1
1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
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Description

Description

Choose one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available with the Thermo Scientific™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody.

Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSβ, which binds to insertion/deletion loops in DNA.

Host Species: Mouse

Clone: 25D12

Isotype: IgG1/κ

Species Reactivity: Human. Others not tested.

Immunogen: Recombinant human MSH2 protein

Molecular Weight: ~102kDa

Positive Control: Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Specifications

Specifications

MSH2 (Mismatch Repair Protein 2) Ab-1
Immunohistochemistry (Paraffin)
Unconjugated
IVD
Primary
25D12
Monoclonal
Murine
DNA Repair
Recombinant human MSH2 protein
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