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MSL1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548690

Catalog No. PA548690


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Description

Description

Predicted to react with mouse based on sequence homology.

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at  ft.Lys-16 ft. (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at  ft.Lys-34 ft. (H2BK34Ub). This modification in turn stimulates histone H3 methylation at  ft.Lys-4 ft. (H3K4me) and  ft.Lys-79 ft. (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
Specifications

Specifications

MSL1
Polyclonal
Unconjugated
MSL1
Liquid
MSL1
KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human MSL1.
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
Q68DK7
Male-specific lethal 1 homolog, MSL-1, Male-specific lethal 1-like 1, MSL1-like 1, Male-specific lethal-1 homolog 1, MSL1, MSL1L1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
339287
Documents
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