MSL2 Mouse anti-Human, Clone: OTI4G7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527413
DescriptionComponent of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at ft.Lys-35 ft. (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at ft.Lys-4 ft. (H3K4me) and ft.Lys-79 ft. (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|KIAA1585; MSL2L1; RNF184|
|-20° C, Avoid Freeze/Thaw Cycles|
|Full length human recombit protein of MSL2 produced in E.coli|
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