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MSL2 Mouse anti-Human, Clone: OTI4G7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527413

Catalog No. PIMA527413


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Description

Description

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at  ft.Lys-35 ft. (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at  ft.Lys-4 ft. (H3K4me) and  ft.Lys-79 ft. (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Specifications

Specifications

MSL2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9HCI7
KIAA1585; MSL2L1; RNF184
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
55167
Western Blot
OTI4G7
Unconjugated
MSL2
Liquid
MSL2
Full length human recombit protein of MSL2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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