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MTA3 Mouse anti-Human, Clone: OTI2B8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527203

Catalog No. PIMA527203


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Description

Description

Metastasis-associated protein 3 (MTA3) is a subunit of the Mi-2/NuRD transcriptional corepressor complex. MTA3 and the Mi-2/NuRD complex mediate repression of Snail in breast cancer cells where MTA3 works to maintain a differentiated, epithelial status. The protein is involved in gene expression regulation by covalent modifications of histone proteins. There are two known isoforms of MTA3, a short and a long form. The short isoform binds to ER and sequesters it to the cytoplasm and betters non-genomic responses, whereas the long form is found in the nucleus. MTA3 is widely expressed in with highest expression in brain, adrenal glands, ovaries and virgin mammary glands. It has been found to be expressed in higher levels in tumors than in adjacent normal tissue in the same individual.
Specifications

Specifications

MTA3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9BTC8
metastasis associated family, member 3, metastasis associated gene family, member 3, metastasis-associated protein MTA3
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
57504
Western Blot
OTI2B8
Unconjugated
MTA3
Liquid
MTA3
Human recombit protein fragment corresponding to amino acids 1-259 of MTA3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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