MTDH Monoclonal Antibody (OTI1B6), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA804490

Catalog No. 50-168-0275

Description

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Specifications

• Antigen: MTDH
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q86UE4
• Gene Symbols: MTDH
• Immunogen: Human recombit protein fragment corresponding to amino acids 70-582 of human MTDH produced in SF9 cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1B6
• Conjugate: Unconjugated
• Gene: MTDH
• Gene Alias: 3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 92140
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid