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MTDH Mouse anti-Human, Clone: OTI1E7, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF803707

Catalog No. 50-166-6636


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
Specifications

Specifications

MTDH
Monoclonal
Unconjugated
MTDH
Lyophilized
MTDH
Human recombit protein fragment corresponding to amino acids 70-582 of human MTDH produced in SF9 cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI1E7
PBS with 8% trehalose and no preservative; pH 7.3
Q86UE4
3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
92140
SDS
Documents
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